Robert De Niro

Jack Byrnes

Ben Stiller

Greg Focker

Owen Wilson

Kevin Rawley

Dustin Hoffman

Bernie Focker

Barbra Streisand

Rozalin Focker

Blythe Danner

Dina Byrnes

Teri Polo

Pam Byrnes-Focker

Jessica Alba

Andi Garcia

Laura Dern

Prudence

Kevin Hart

Nurse Louis

Daisy Tahan

Samantha Focker

Colin Baiocchi

Henry Focker

Tom McCarthy

Dr. Bob

Harvey Keitel

Randy Weir

Yul Vazquez

Junior

Jack Axelrod

Chappy

Olga Fonda

Svetlana

Trula M. Marcus

Stage Producer

Jake Keiffer

Rufus

Rob Huebel

Sleazy Doctor

John DiMaggio

EMT

Jordan Peele

EMT

Kelli Kirkland

EMT

Deepak Chopra

Deepak Chopra

Robbie Tucker

EHS Tough Kid

Nick Kroll

Young Doctor

Sergio Calderón

Gustavo

David Pressman

Doctor

Hugh Dane

Doctor

Amy Stiller

Kristen

Richard Cotovsky

Newspaper Vendor

Paul Herman

Caricature Artist

Robert Miano

Party Parent

Roy Jones Jr.

Party Parent

Vladimir Kubr

Ballpit Kid

Michael Naughton

Anatomy Professor

Stan Egi

Man on Subway

Michelle Castillo

Flamenco Dancer

Jillana Laufer

Flamenco Dancer

Gary Sievers

Spanish Square Patron (uncredited)

Arnold Chon

Monk (uncredited)