Zach Braff

Tom Reilly

Amanda Peet

Sofia Kowalski

Jason Bateman

Chip Sanders

Charles Grodin

Bob Kowalski

Mia Farrow

Amelia Kowalski

Lucian Maisel

Wesley

Donal Logue

Don Wollebin

Amy Poehler

Carol Lane

Fred Armisen

Manny

Bob Stephenson

Doug

Yaffit Hallely

Woman

Josh Charles

Forrest Mead

Marin Hinkle

Karen

Yul Vazquez

Paco

Paul Rudd

Leon

Nick Grodin

Summers

Robert John Burke

Colonel

Romany Malco

Doctor Hakim Oliver

Carole Troll

Nurse

Edmund Lyndeck

Mr. Hordhaus

Amy Adams

Abby March

Lauren Weedman

Alice

Michael Cumpsty

Jack Connor

John Benjamin Hickey

Wesley's Dad

Frank Girardeau

Fire Inspector

Ian Hyland

Steve

Tarina Pouncy

Ticket Agent

Sig Libowitz

Hassidic Guy

Eddie McGee

Wheelchair Basketball Player #2

Shevy Gutierrez

Lower East Sider (uncredited)