John Wayne

Lt. Col. Kirby Yorke

Maureen O'Hara

Mrs. Kathleen Yorke

Ben Johnson

Trooper Travis Tyree

Claude Jarman Jr.

Trooper Jefferson 'Jeff' Yorke

Harry Carey, Jr.

Trooper Daniel 'Sandy' Boone

Chill Wills

Dr. Wilkins

J. Carrol Naish

Lt. Gen. Philip Sheridan

Victor McLaglen

Sgt. Maj. Timothy Quincannon

Grant Withers

U.S. Deputy Marshal

Steve Pendleton

Capt. Prescott

Karolyn Grimes

Margaret Mary

Alberto Morin

Lieutenant

Ken Curtis

Donnelly - Regimental Singer (uncredited)

Hugh Farr

Regimental Singer (uncredited)

Shug Fisher

Regimental Singer/Bugler (uncredited)

Cliff Lyons

Soldier (uncredited)

Jack Pennick

Sergeant (uncredited)

Lloyd Perryman

Regimental Singer (uncredited)

Chuck Roberson

Officer/Indian Fires Arrow Into Col. York's Chest (uncredited)

Patrick Wayne

Boy (uncredited)